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3D cell culture
3D cell culture represents a paradigm shift from traditional monolayer techniques, allowing researchers to grow cells in environments that mimic natural tissue architecture. By facilitating three-dimensional interactions between cells and their surroundings, this method provides more accurate data regarding cellular signaling, metabolic gradients, and the mechanical forces experienced in vivo.
The implementation of spheroids and organoids allows for the study of complex biological processes such as nutrient diffusion and oxygen transport, which are often absent in 2D models. These systems are increasingly utilized in oncology to understand tumor heterogeneity and in regenerative medicine to engineer functional tissue replacements.